منابع مشابه
Pulmonary hypertension in hemolytic anemias
Pulmonary hypertension (PH) has been reported with nearly all forms of the inherited as well as the acquired hemolytic anemias. Recent research investigating the pathophysiology of PH in sickle cell disease and thalassemia has helped elucidate the central role of hemolysis-mediated endothelial dysfunction in the development of PH in these populations. Although the most appropriate treatment of ...
متن کاملHemolytic Anemias: Red Blood Cell Membrane and Metabolic Defects
The mature erythrocyte differs from all other cells in the body. Lacking a nucleus, DNA, RNA, and ribosomes, it cannot synthesize RNA, DNA, or protein. It does not divide, it has no mitochondria, it cannot perform the Krebs cycle, and it lacks an electron transport system for oxidative phos phorylation. After enucleation, the reticulocyte, the precursor of the mature erythrocyte, leaves the ma...
متن کاملTreatment of autoimmune hemolytic anemias.
Autoimmune hemolytic anemia (AIHA) is a relatively uncommon disorder caused by autoantibodies directed against self red blood cells. It can be idiopathic or secondary, and classified as warm, cold (cold hemagglutinin disease (CAD) and paroxysmal cold hemoglobinuria) or mixed, according to the thermal range of the autoantibody. AIHA may develop gradually, or have a fulminant onset with life-thre...
متن کاملSerology of Acquired Hemolytic Anemias.
I F A SERUM contains a gamma globulin which will react with ( agglutinate, hemolyze or sens tize ) certain enetically well-defined red blood cells but not others, it is said to possess an antibody and the antibody is said to be specific for a certain property of the red cells. Thus the specificity of an antibody depends on this selective reactivity. This is often difficult to demonstrate if the...
متن کاملRecommendations for splenectomy in hereditary hemolytic anemias
Hereditary hemolytic anemias are a group of disorders including red cell membrane defects, red blood cells enzyme disorders, congenital dyserythropoietic anemias, thalassemia syndromes and haemoglobinopathies. As damaged red blood cells passing through the spleen red pulp are efficiently removed by splenic macrophages, splenectomy is one possible therapeutic approach to the management of severe...
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ژورنال
عنوان ژورنال: Immunohematology
سال: 2020
ISSN: 0894-203X,1930-3955
DOI: 10.21307/immunohematology-2019-608